Cover Feature: Encapsulating pH‐Responsive Doxorubicin–Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy (Chem. Eur. J. 65/2017)

Zinc(II) phthalocyanine (ZnPc) was conjugated with doxorubicin (Dox) through an acid‐cleavable hydrazone linker, and the resulting conjugate was encapsulated into mesoporous silica nanoparticles. Upon internalization into cancer cells, Dox was released after acidic cleavage of the hydrazone linker....

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Veröffentlicht in:Chemistry : a European journal 2017-11, Vol.23 (65), p.16411-16411
Hauptverfasser: Wong, Roy C. H, Ng, Dennis K. P, Fong, Wing‐Ping, Lo, Pui‐Chi
Format: Artikel
Sprache:eng
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Zusammenfassung:Zinc(II) phthalocyanine (ZnPc) was conjugated with doxorubicin (Dox) through an acid‐cleavable hydrazone linker, and the resulting conjugate was encapsulated into mesoporous silica nanoparticles. Upon internalization into cancer cells, Dox was released after acidic cleavage of the hydrazone linker. The synergistic effect of the chemocytotoxic agent and the singlet oxygen generated upon irradiation of the encapsulated ZnPc killed the cells efficiently. These nanoparticles thus exhibit dual functionality as nanophotosensitizers for photodynamic therapy and as nanoplatforms for pH‐controlled drug release. More information can be found in the Full Paper by D. K. P. Ng, P.‐C. Lo et al. on page 16505.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201704058