[alpha]2-glycine receptors modulate adult hippocampal neurogenesis and spatial memory

The [alpha]2-glycine receptors (GlyRs) play important roles during early central nervous system development. However, these receptors' possible involvement in neurodevelopmental events occurring in the adult brain remains to be explored. Adult hippocampal neurogenesis (AHN) is the process by wh...

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Veröffentlicht in:Developmental neurobiology (Hoboken, N.J.) N.J.), 2017-12, Vol.77 (12), p.1430
Hauptverfasser: Lin, Min-Shan, Xiong, Wen-Chao, Li, Shu-Ji, Gong, Zhi, Cao, Xiong, Kuang, Xiao-Jing, Zhang, Yuan, Gao, Tian-Ming, Mechawar, Naguib, Liu, Ce, Zhu, Xin-Hong
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Sprache:eng
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Zusammenfassung:The [alpha]2-glycine receptors (GlyRs) play important roles during early central nervous system development. However, these receptors' possible involvement in neurodevelopmental events occurring in the adult brain remains to be explored. Adult hippocampal neurogenesis (AHN) is the process by which new granule cell neurons are added to the dentate gyrus (DG) throughout adulthood. In this study, we observed that hippocampal adult neural stem cells (ANSCs) express [alpha]2-containing GlyRs. Pharmacological inhibition of GlyRs by strychnine or picrotoxin decreased the proliferation of ANSCs, both in vivo and in vitro. Mice knockout for glra2, the gene coding for the GlyR [alpha]2 subunit, were determined to display impaired AHN, and this phenomenon was accompanied by deficits in spatial memory. These results, which reveal neurodevelopmental roles for [alpha]2-GlyRs in the adult brain, may be clinically relevant, given that a mutation in GLAR2, as well as AHN impairments, have been reported in autism spectrum disorder. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1430-1441, 2017
ISSN:1932-8451
1932-846X
DOI:10.1002/dneu.22549