Novel 4‐arylaminoquinoline‐3‐carbonitriles as Inhibitors of HIV‐1 Reverse Transcriptase

Novel 4‐arylaminoquinoline‐3‐carbonitriles as Inhibitors of HIV‐1 Reverse Transcriptase

This paper describes the synthesis of several new 4‐arylaminoquinoline‐3‐carbonitriles derivatives. These were evaluated on the activity reverse transcriptase (RT) of HIV‐1. Most of the synthesized compounds showed significant in vitro inhibition of RT enzyme, especially derivative 3h (IC50 = ...

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Veröffentlicht in:Journal of heterocyclic chemistry 2017-11, Vol.54 (6), p.3051-3055
Hauptverfasser: Melo, Beatriz C. L., Bernardino, Alice M. R., Polillo, Gustavo, Pereira, Helena S., Paixão, Izabel C. P., Ribeiro, Michele S., Borges, Julio C.
Format: Artikel
Sprache:eng
Schlagworte:
Cytotoxicity
Derivatives
Toxicity
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Zusammenfassung:This paper describes the synthesis of several new 4‐arylaminoquinoline‐3‐carbonitriles derivatives. These were evaluated on the activity reverse transcriptase (RT) of HIV‐1. Most of the synthesized compounds showed significant in vitro inhibition of RT enzyme, especially derivative 3h (IC50 = 
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2914