Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives

A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC‐510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these title compounds exhibited 100% mortality at 50 ...

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Veröffentlicht in:Journal of heterocyclic chemistry 2017-11, Vol.54 (6), p.3395-3402
Hauptverfasser: Cao, Shengwen, Liu, Aiping, Liu, Weidong, Liu, Xingping, Ren, Yeguo, Pei, Hui, Huang, Lu, Zheng, Xi, Huang, Mingzhi, Wu, Daoxin
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Sprache:eng
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Zusammenfassung:A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC‐510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these title compounds exhibited 100% mortality at 50 mg/L against Aphis fabae. In particular, the compound 11c displayed the best activity: Its LC50 value achieved 1.45 mg/L, and its insecticidal potency is comparable with that of NC‐510.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2961