An Efficient Synthesis of Pyrrolo[1,2‐a]quinoxalines by Copper‐Catalyzed C−H Activation of Arylacetic Acids

An efficient and convenient synthesis of pyrrolo[1,2‐a]quinoxalines from 1‐(2‐aminoaryl)pyrrole and arylacetic acids has been described by using a combination of CuSO4 as the catalyst and 2,2′‐bipyridyl as the ligand in the presence of O2 as an oxidant. The prominent features of this method are the use of readily available starting materials, inexpensive catalyst, broad substrate scope and high product yields. Copper‐catalyzed cascade protocol for the synthesis of pyrrolo[1,2‐a]quinoxaline is reported through C−H activation of arylacetic acids under O2 atmosphere. The remarkable features of this protocol are the use of easily available starting materials, cheap catalyst, wide functional group tolerance and good to excellent yields of the products.