Copper‐Catalyzed Decarboxylative Alkylation of Terminal Alkynes

Copper‐Catalyzed Decarboxylative Alkylation of Terminal Alkynes

A copper‐catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C(sp3)−C(sp) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered t...

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Veröffentlicht in:Advanced synthesis & catalysis 2017-11, Vol.359 (21), p.3720-3724
Hauptverfasser: Ye, Changqing, Li, Yajun, Bao, Hongli
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Alkynes
Aromatic compounds
Copper
Copper-catalysis
Decarboxylation
Peroxides
Sonogashira coupling
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Zusammenfassung:A copper‐catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C(sp3)−C(sp) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered the alkylated internal alkynes with good to high performances. Mechanism studies suggested that this reaction involves a free radical pathway.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201700798