Synthesis of N‐Nitroso CHF2‐Pyrazolines and Their Transformation into CHF2‐Isoxazolines and ‐Pyrazoles

Synthesis of N‐Nitroso CHF2‐Pyrazolines and Their Transformation into CHF2‐Isoxazolines and ‐Pyrazoles

N‐Nitroso CHF2‐pyrazolines were synthesized from in situ generated difluoromethyldiazomethane (CF2HCHN2), tert‐butyl isonitrite (tBuONO), and alkenes. The synthesis of representative CHF2‐pyrazoles and CHF2‐oxazolines was also performed. N‐Nitroso CHF2‐pyrazolines are synthesized from in situ genera...

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Veröffentlicht in:European journal of organic chemistry 2017-11, Vol.2017 (41), p.6114-6120
Hauptverfasser: Lebed, Pavlo S., Fenneteau, Johan, Wu, Yong, Cossy, Janine, Mykhailiuk, Pavel K.
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Cycloaddition
Diazo compounds
Fluorinated compounds
Fluorine
Heterocycles
Synthesis
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Zusammenfassung:N‐Nitroso CHF2‐pyrazolines were synthesized from in situ generated difluoromethyldiazomethane (CF2HCHN2), tert‐butyl isonitrite (tBuONO), and alkenes. The synthesis of representative CHF2‐pyrazoles and CHF2‐oxazolines was also performed. N‐Nitroso CHF2‐pyrazolines are synthesized from in situ generated difluoromethyldiazomethane (CF2HCHN2), tert‐butyl isonitrite (tBuONO), and alkenes. The synthesis of representative CHF2‐pyrazoles and CHF2‐oxazolines is also performed.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201700803