TCT-425 Impact of cerebral protection in aortic stenosis patients treated with transcatheter aortic valve replacement on functional and structural integrity of the brain: results of a combined patient-level analysis of three randomized controlled trials

In the protected areas, total median new lesion volume was greater for subjects treated with a self-expandable (SE) vs balloon-expandable (BE) valves in both the Treatment and Control groups, and as expected, protected area total median new lesion volume was higher in the Control group than the Treatment group for both BE (152.9[31.6;319.0] vs 71.2[31.6;274.2]), and SE (359.3[172.9;930.3] and 173.5[58.4;414.0]) valves. Conclusion This patient-level pooled analysis demonstrated that the use of CEP resulted in significant reduction (p=0.02) in total new lesion volume in protected territories post TAVR independent of valve type selection and pre-existing lesion burden.