TCT-254 Intracoronary versus intravenous infusion of adenosine for the accurate assessment of fractional flow reserve: the hyperemic study

Methods The HYPEREMIC study was a randomized single blinded crossover investigation to evaluate the effectivenes and safety of a novel dedicated over-the-wire infusion micro-catheter (HYPEREM™IC) for measuring FFR using IC non-weight adjusted adenosine infusion versus the standard IV method. The total IC dose required is about 1.5% of the equivalent IV dose yet achieved a more rapid and stable state of hyperemia. [...]FFR values were consistently lower with IC infusion with more lesions classified as ischemic.