TCT-204 Minimizing the Sham Effect to Optimize Hypertension Studies: Analyses from the Wave IV study

The top level data from the Wave IV trial showed a trend toward greater blood pressure improvement in the sham group than in the treatment group for both ambulatory blood pressure and office blood pressure. Subgroups included an analysis of the time based learning curve as the trial proceeded, age, bmi, pulse pressure, stability of the run in period, baseline blood pressure, type and quality of sedation, and power levels.