HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS
Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffe...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 1994-08, Vol.33 (8), p.702-706 |
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| creator | PARTSCH, G. PETERA, P. LEEB, B. MERETEY, K. KOO, E. DUNKY, A. BRÖLL, H. ZAMANI, O. FERTSCHAK, W. MATUCCI-CERINIC, M. SMOLEN, J. S. |
| description | Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffering from OA (n = 13), RA (n = 17), and PsA (n = 20). Free collagenolytic activity was low in the crude OA SF (1.80 ± 1.35 μg released collagen/min/ml SF) and almost equally low in RA SF (2.35 ± 1.80 μg released collagen/min/ml SF; P>0.3). The PsA SF, however, exhibited a significantly higher free collagenolytic activity (5.63 ± 5.69 μg released collagen/min/ml SF; P |
| doi_str_mv | 10.1093/rheumatology/33.8.702 |
| format | Article |
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S.</creator><creatorcontrib>PARTSCH, G. ; PETERA, P. ; LEEB, B. ; MERETEY, K. ; KOO, E. ; DUNKY, A. ; BRÖLL, H. ; ZAMANI, O. ; FERTSCHAK, W. ; MATUCCI-CERINIC, M. ; SMOLEN, J. S.</creatorcontrib><description>Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffering from OA (n = 13), RA (n = 17), and PsA (n = 20). Free collagenolytic activity was low in the crude OA SF (1.80 ± 1.35 μg released collagen/min/ml SF) and almost equally low in RA SF (2.35 ± 1.80 μg released collagen/min/ml SF; P>0.3). The PsA SF, however, exhibited a significantly higher free collagenolytic activity (5.63 ± 5.69 μg released collagen/min/ml SF; P<0.05 in comparison to OA and RA SF). The treatment of the SF with trypsin further activated collagenolytic activity in each group (OA 2.17 ± 135 μg released collagen/min/ml SF; RA 6.48 ± 6.73 μg released collagen/min/ml SF; PsA 11.24 ± 5.02 μg released collagen/min/ml SF) and yielded significant differences between OA and RA, OA and PsA, and RA and PsA SF (P < 0.05). Concomitantly with the collagenolytic activity, the αl-antitrypsin and α2-macroglobulin concentrations of the SF were measured. In SF from patients with PsA (172.9 ± 69.4 mg/100 ml) and RA (190.6 ± 64.7 mg/100 ml) the αl-antitrypsin was significantly higher than in those from OA SF (106.1 ± 39.2 mg/100 ml). On the other hand the α2-macroglobulin concentration was significantly lower in PsA SF (70.5 ± 17.2 mg/100 ml) in comparison with OA (91.9 ± 323 mg/100 ml; P < 0.03) and RA (96.4 ± 35.0 mg/100 ml P < 0.05) SF. The results of the present study show that in contrast to RA and OA SF, PsA SF contain an unexpectedly high free collagenolytic activity which is significantly correlated with the low α2-macroglobulin concentration in these SF</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/33.8.702</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Collagenase activity ; Inflammatory disease ; Psoriatic arthritis ; Synovial fluid</subject><ispartof>Rheumatology (Oxford, England), 1994-08, Vol.33 (8), p.702-706</ispartof><rights>Copyright Oxford University Press(England) Aug 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c231t-6ec8c70069af797004988075670e8abbde2a9aab6a2b9d0b57802b3c02163b563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>PARTSCH, G.</creatorcontrib><creatorcontrib>PETERA, P.</creatorcontrib><creatorcontrib>LEEB, B.</creatorcontrib><creatorcontrib>MERETEY, K.</creatorcontrib><creatorcontrib>KOO, E.</creatorcontrib><creatorcontrib>DUNKY, A.</creatorcontrib><creatorcontrib>BRÖLL, H.</creatorcontrib><creatorcontrib>ZAMANI, O.</creatorcontrib><creatorcontrib>FERTSCHAK, W.</creatorcontrib><creatorcontrib>MATUCCI-CERINIC, M.</creatorcontrib><creatorcontrib>SMOLEN, J. S.</creatorcontrib><title>HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS</title><title>Rheumatology (Oxford, England)</title><description>Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffering from OA (n = 13), RA (n = 17), and PsA (n = 20). Free collagenolytic activity was low in the crude OA SF (1.80 ± 1.35 μg released collagen/min/ml SF) and almost equally low in RA SF (2.35 ± 1.80 μg released collagen/min/ml SF; P>0.3). The PsA SF, however, exhibited a significantly higher free collagenolytic activity (5.63 ± 5.69 μg released collagen/min/ml SF; P<0.05 in comparison to OA and RA SF). The treatment of the SF with trypsin further activated collagenolytic activity in each group (OA 2.17 ± 135 μg released collagen/min/ml SF; RA 6.48 ± 6.73 μg released collagen/min/ml SF; PsA 11.24 ± 5.02 μg released collagen/min/ml SF) and yielded significant differences between OA and RA, OA and PsA, and RA and PsA SF (P < 0.05). Concomitantly with the collagenolytic activity, the αl-antitrypsin and α2-macroglobulin concentrations of the SF were measured. In SF from patients with PsA (172.9 ± 69.4 mg/100 ml) and RA (190.6 ± 64.7 mg/100 ml) the αl-antitrypsin was significantly higher than in those from OA SF (106.1 ± 39.2 mg/100 ml). On the other hand the α2-macroglobulin concentration was significantly lower in PsA SF (70.5 ± 17.2 mg/100 ml) in comparison with OA (91.9 ± 323 mg/100 ml; P < 0.03) and RA (96.4 ± 35.0 mg/100 ml P < 0.05) SF. The results of the present study show that in contrast to RA and OA SF, PsA SF contain an unexpectedly high free collagenolytic activity which is significantly correlated with the low α2-macroglobulin concentration in these SF</description><subject>Collagenase activity</subject><subject>Inflammatory disease</subject><subject>Psoriatic arthritis</subject><subject>Synovial fluid</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpNkFtPwjAYhhejiYj-BJPG-0EPbF0vmzFY49zINhbwpulGURAddiORf-8Ihnj1vfnyHpLHsh4RHCDIyNC868Onautd_XYcEjLwBhTiK6uHRi62ISH4-qLx6Na6a5othNBBxOtZs1BMQzBJgwDweAwingdxDvwkivg0iHnWvf1cFCJfAhGDWZakgufCBzzNw1TkIgPZMk4KwSMwieZinN1bN2u1a_TD3-1b80mQ-6EdJVPh88iuMEGt7erKqyiELlNryjoxYp4HqeNSqD1VliuNFVOqdBUu2QqWDvUgLkkFMXJJ6bikbz2de_em_j7oppXb-mC-ukmJ2KmGEdSZnLOpMnXTGL2We7P5VOYoEZQndvI_O0mI9GTHrsvZ59ymafXPJaTMh3QpoY4MF69y8QKL57BIZUp-AR0MbeY</recordid><startdate>199408</startdate><enddate>199408</enddate><creator>PARTSCH, G.</creator><creator>PETERA, P.</creator><creator>LEEB, B.</creator><creator>MERETEY, K.</creator><creator>KOO, E.</creator><creator>DUNKY, A.</creator><creator>BRÖLL, H.</creator><creator>ZAMANI, O.</creator><creator>FERTSCHAK, W.</creator><creator>MATUCCI-CERINIC, M.</creator><creator>SMOLEN, J. 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S.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PARTSCH, G.</au><au>PETERA, P.</au><au>LEEB, B.</au><au>MERETEY, K.</au><au>KOO, E.</au><au>DUNKY, A.</au><au>BRÖLL, H.</au><au>ZAMANI, O.</au><au>FERTSCHAK, W.</au><au>MATUCCI-CERINIC, M.</au><au>SMOLEN, J. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><date>1994-08</date><risdate>1994</risdate><volume>33</volume><issue>8</issue><spage>702</spage><epage>706</epage><pages>702-706</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffering from OA (n = 13), RA (n = 17), and PsA (n = 20). Free collagenolytic activity was low in the crude OA SF (1.80 ± 1.35 μg released collagen/min/ml SF) and almost equally low in RA SF (2.35 ± 1.80 μg released collagen/min/ml SF; P>0.3). The PsA SF, however, exhibited a significantly higher free collagenolytic activity (5.63 ± 5.69 μg released collagen/min/ml SF; P<0.05 in comparison to OA and RA SF). The treatment of the SF with trypsin further activated collagenolytic activity in each group (OA 2.17 ± 135 μg released collagen/min/ml SF; RA 6.48 ± 6.73 μg released collagen/min/ml SF; PsA 11.24 ± 5.02 μg released collagen/min/ml SF) and yielded significant differences between OA and RA, OA and PsA, and RA and PsA SF (P < 0.05). Concomitantly with the collagenolytic activity, the αl-antitrypsin and α2-macroglobulin concentrations of the SF were measured. In SF from patients with PsA (172.9 ± 69.4 mg/100 ml) and RA (190.6 ± 64.7 mg/100 ml) the αl-antitrypsin was significantly higher than in those from OA SF (106.1 ± 39.2 mg/100 ml). On the other hand the α2-macroglobulin concentration was significantly lower in PsA SF (70.5 ± 17.2 mg/100 ml) in comparison with OA (91.9 ± 323 mg/100 ml; P < 0.03) and RA (96.4 ± 35.0 mg/100 ml P < 0.05) SF. The results of the present study show that in contrast to RA and OA SF, PsA SF contain an unexpectedly high free collagenolytic activity which is significantly correlated with the low α2-macroglobulin concentration in these SF</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1093/rheumatology/33.8.702</doi><tpages>5</tpages></addata></record> |
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| source | Alma/SFX Local Collection |
| subjects | Collagenase activity Inflammatory disease Psoriatic arthritis Synovial fluid |
| title | HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS |
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