HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS

HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS

Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffe...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 1994-08, Vol.33 (8), p.702-706
Hauptverfasser: PARTSCH, G., PETERA, P., LEEB, B., MERETEY, K., KOO, E., DUNKY, A., BRÖLL, H., ZAMANI, O., FERTSCHAK, W., MATUCCI-CERINIC, M., SMOLEN, J. S.
Format: Artikel
Sprache:eng
Schlagworte:
Collagenase activity
Inflammatory disease
Psoriatic arthritis
Synovial fluid
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Zusammenfassung:Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffering from OA (n = 13), RA (n = 17), and PsA (n = 20). Free collagenolytic activity was low in the crude OA SF (1.80 ± 1.35 μg released collagen/min/ml SF) and almost equally low in RA SF (2.35 ± 1.80 μg released collagen/min/ml SF; P>0.3). The PsA SF, however, exhibited a significantly higher free collagenolytic activity (5.63 ± 5.69 μg released collagen/min/ml SF; P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/33.8.702