Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors
A comparative kinetic study of the inhibition of urea hydrolysis by 9 substituted 1,5,6,7-tetrahydro-4 H -benzimidazol-4-ones (BI I–IX) has been carried out. The inhibition had reversible competitive mode; the inhibition constants K i , varied from 29 to 754 μM in dependence of structure of BI I–IX....
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| Veröffentlicht in: | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2009-03, Vol.3 (1), p.71-76 |
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| container_title | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry |
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| creator | Tarun, E. I. Zheldakova, T. A. Metelitza, D. I. |
| description | A comparative kinetic study of the inhibition of urea hydrolysis by 9 substituted 1,5,6,7-tetrahydro-4
H
-benzimidazol-4-ones (BI I–IX) has been carried out. The inhibition had reversible competitive mode; the inhibition constants
K
i
, varied from 29 to 754 μM in dependence of structure of BI I–IX. Three BI I–IX, characterized by the
K
i
values ranged from 29 to 82 μM, may be used as potential therapeutic agents in gastroenterology for treatment of gastroduodenal ulcers. |
| doi_str_mv | 10.1134/S1990750809010107 |
| format | Article |
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K
i
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K
i
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K
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K
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H
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K
i
, varied from 29 to 754 μM in dependence of structure of BI I–IX. Three BI I–IX, characterized by the
K
i
values ranged from 29 to 82 μM, may be used as potential therapeutic agents in gastroenterology for treatment of gastroduodenal ulcers.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S1990750809010107</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1990-7508 |
| ispartof | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry, 2009-03, Vol.3 (1), p.71-76 |
| issn | 1990-7508 1990-7516 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biochemistry Bioorganic Chemistry Chemistry Chemistry and Materials Science Digestive system Enzymes Experimental Studies Kinetics Medicinal Chemistry Soybeans Ulcers |
| title | Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors |
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