Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors

Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors

A comparative kinetic study of the inhibition of urea hydrolysis by 9 substituted 1,5,6,7-tetrahydro-4 H -benzimidazol-4-ones (BI I–IX) has been carried out. The inhibition had reversible competitive mode; the inhibition constants K i , varied from 29 to 754 μM in dependence of structure of BI I–IX....

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Veröffentlicht in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2009-03, Vol.3 (1), p.71-76
Hauptverfasser: Tarun, E. I., Zheldakova, T. A., Metelitza, D. I.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Digestive system
Enzymes
Experimental Studies
Kinetics
Medicinal Chemistry
Soybeans
Ulcers
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Zusammenfassung:A comparative kinetic study of the inhibition of urea hydrolysis by 9 substituted 1,5,6,7-tetrahydro-4 H -benzimidazol-4-ones (BI I–IX) has been carried out. The inhibition had reversible competitive mode; the inhibition constants K i , varied from 29 to 754 μM in dependence of structure of BI I–IX. Three BI I–IX, characterized by the K i values ranged from 29 to 82 μM, may be used as potential therapeutic agents in gastroenterology for treatment of gastroduodenal ulcers.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750809010107