A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology‐dependent. The redox modulatory effect of Mn3O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)‐like cellular model, indicating that manganese‐based nanomaterials having multi‐enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS‐mediated neurological disorders. The Mn3O4 nanozyme (Mnf) shows a remarkable redox modulatory effect in human cells by mimicking the three major enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), complementing the cellular defense machinery against oxidative stress. Mnf has the potential to provide cytoprotection to the cells from oxidative damage (ROS=reactive oxygen species).