Metal‐Free Nitration of the C(sp3)−H Bonds of 2‐Oxindoles through Radical Coupling Reaction at Room Temperature

A metal‐free nitration of the C(sp3)−H bonds of 2‐oxindoles with t‐BuONO through radical coupling reaction at room temperature has been developed. Using t‐BuONO both as a nitrating reagent and as an oxidant, to couple with the C(sp3)−H bonds of 2‐oxindoles, thus forming a new C−N bond without using...

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Veröffentlicht in:Advanced synthesis & catalysis 2017-10, Vol.359 (20), p.3551-3554
Hauptverfasser: Wei, Wen‐Ting, Zhu, Wen‐Ming, Ying, Wei‐Wei, Wang, Yi‐Ning, Bao, Wen‐Hui, Gao, Le‐Han, Luo, Yun‐Jie, Liang, Hongze
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Sprache:eng
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Zusammenfassung:A metal‐free nitration of the C(sp3)−H bonds of 2‐oxindoles with t‐BuONO through radical coupling reaction at room temperature has been developed. Using t‐BuONO both as a nitrating reagent and as an oxidant, to couple with the C(sp3)−H bonds of 2‐oxindoles, thus forming a new C−N bond without using any other reagents. This reaction provides a green and straightforward approach to some useful 3‐nitro‐2‐oxindoles in moderate to good yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201700870