Metal‐Free Nitration of the C(sp3)−H Bonds of 2‐Oxindoles through Radical Coupling Reaction at Room Temperature
A metal‐free nitration of the C(sp3)−H bonds of 2‐oxindoles with t‐BuONO through radical coupling reaction at room temperature has been developed. Using t‐BuONO both as a nitrating reagent and as an oxidant, to couple with the C(sp3)−H bonds of 2‐oxindoles, thus forming a new C−N bond without using...
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Veröffentlicht in: | Advanced synthesis & catalysis 2017-10, Vol.359 (20), p.3551-3554 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A metal‐free nitration of the C(sp3)−H bonds of 2‐oxindoles with t‐BuONO through radical coupling reaction at room temperature has been developed. Using t‐BuONO both as a nitrating reagent and as an oxidant, to couple with the C(sp3)−H bonds of 2‐oxindoles, thus forming a new C−N bond without using any other reagents. This reaction provides a green and straightforward approach to some useful 3‐nitro‐2‐oxindoles in moderate to good yields. |
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ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201700870 |