Peptides: Rational Design of Membrane‐Pore‐Forming Peptides (Small 40/2017)

In article number 1701316, by Gisbert Schneider and co‐workers, a novel peptide descriptor enables the rational design of peptides based on their topological hydrophobic distribution. Applying this descriptor, a computational method generates an innovative peptide inspired by a natural template. This peptide is then trialed and optimized for its ability to disrupt bacterial cells by forming ordered, pore‐like structures in membranes in an entropy‐driven mechanism.