GW28-e0319 The role of soluble Guanylyl Cyclase β1/α1 on Doxorubicin-induced cardiomyopathy

GW28-e0319 The role of soluble Guanylyl Cyclase β1/α1 on Doxorubicin-induced cardiomyopathy

Objectives Signaling of soluble guanylate cyclase (sGC) has protective effect on cardiovascular disease and chemosensitization effect on cancer. Methods 9-week-old male Sprague Dawley rats were administrated 3.33 mg/kg Dox (total dose: 20 mg/kg) and 1 mg/kg Bay 60-2770 (total dose: 6 mg/kg) for 2 we...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C57-C57
Hauptverfasser: Zhao, Xiaoxiao, Like, Guan
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiomyocytes
Cardiomyopathy
Doxorubicin
Guanylate cyclase
Rodents
Studies
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Zusammenfassung:Objectives Signaling of soluble guanylate cyclase (sGC) has protective effect on cardiovascular disease and chemosensitization effect on cancer. Methods 9-week-old male Sprague Dawley rats were administrated 3.33 mg/kg Dox (total dose: 20 mg/kg) and 1 mg/kg Bay 60-2770 (total dose: 6 mg/kg) for 2 weeks, divided 6 times by intraperitoneal injection and gavage respectively.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.195