GW28-e0999 IL-33 promotes IL-10 productions: mechanism of IL-33 reducing macrophages foam cell formation

GW28-e0999 IL-33 promotes IL-10 productions: mechanism of IL-33 reducing macrophages foam cell formation

Methods Serum levels of IL-33 and IL-10 in coronary artery disease (CAD) patients were assessed using enzyme linked immunosorbent assay and their relationships were explored with Spearman's correlation. IL-33 induced Sp1 accumulation in nucleus, phosphorylation of STAT3 and STAT4 but only STAT3...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C38-C39
Hauptverfasser: Zhang, HaiFeng, Lin, YongQing, Liu, WenHao, Wang, ShaoHua, Xu, ChengZhang, Chen, YangXin, Wang, JingFeng
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular disease
Cholesterol
Coronary artery
Interleukin 10
Macrophages
Mutagenesis
Phosphorylation
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Zusammenfassung:Methods Serum levels of IL-33 and IL-10 in coronary artery disease (CAD) patients were assessed using enzyme linked immunosorbent assay and their relationships were explored with Spearman's correlation. IL-33 induced Sp1 accumulation in nucleus, phosphorylation of STAT3 and STAT4 but only STAT3 binding sequences were predicted in the above segment. [...]STAT3 inhibitor dismissed the regulatory effects of IL-33 on IL-10 expression.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.132