GW28-e1131 Cellular Repressor of E1A-Stimulated Genes Protects from Myocardial Ischemia/Reperfusion Injury by Regulating Myocardial Autophagy and Apoptosis

GW28-e1131 Cellular Repressor of E1A-Stimulated Genes Protects from Myocardial Ischemia/Reperfusion Injury by Regulating Myocardial Autophagy and Apoptosis

Objectives Cellular repressor of E1A-stimulated genes (Creg) is a secreted glycoprotein that regulates tissue and cell homeostasis and has been shown to antagonize heart injury; however, little is known about the role of CREG in ischemia/reperfusion injury (IRI). Apoptosis, lysosome formation and fu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C156-C157
Hauptverfasser: Song, Haixu, Yan, Chenghui, Tian, Xiaoxiang, Li, Yang, Yang, Guitang, Peng, Chengfei, Sun, Mingyu, Han, Yaling, Shuang, Wang
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Autophagy
Cardiology
Cardiomyocytes
Ischemia
Myocardial ischemia
Phagocytosis
Proteins
Reperfusion
Rodents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objectives Cellular repressor of E1A-stimulated genes (Creg) is a secreted glycoprotein that regulates tissue and cell homeostasis and has been shown to antagonize heart injury; however, little is known about the role of CREG in ischemia/reperfusion injury (IRI). Apoptosis, lysosome formation and function were detected in both heart tissue and cardiomyocyte cell line H9C2.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.569