GW28-e0704 PCSK1 MUTANT MICE DISPLAY INCREASED APOA1 LEVEL AND DECREASED PLTP ACTIVITIY IN SERUM

GW28-e0704 PCSK1 MUTANT MICE DISPLAY INCREASED APOA1 LEVEL AND DECREASED PLTP ACTIVITIY IN SERUM

Objectives Several proprotein convertase subtilisin/kexin (PCSK) members are involved in high-density lipoprotein (HDL) metabolism. PLTP activity was lower in PCSK1N222D serum when APOA1 and HDL cholesterol concentrations were induced by a diet supplemented with vitamin D, suggesting that lower PLTP...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C64-C65
Hauptverfasser: Choi, Seungbum, Aljakna, Aleksandra, Korstanje, Ron
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cholesterol
Low density lipoprotein
Metabolism
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Zusammenfassung:Objectives Several proprotein convertase subtilisin/kexin (PCSK) members are involved in high-density lipoprotein (HDL) metabolism. PLTP activity was lower in PCSK1N222D serum when APOA1 and HDL cholesterol concentrations were induced by a diet supplemented with vitamin D, suggesting that lower PLTP activity in PCSK1N222D serum is a cause of lipid-free APOA1 induction.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.220