GW28-e0981 Overexpression of PPAR-gamma in mice heart leads to a reduction of connexin 43

GW28-e0981 Overexpression of PPAR-gamma in mice heart leads to a reduction of connexin 43

Methods Relative young (3 weeks) transgenetic cardiac-specific PPAR-γ(MHC-PPAR-γ) overexpression mice with low (PPAR-γ L) and high (PPAR-γ H) levels, and control mice were used. Results Cx43 contents, both in mRNA and protein levels, in heart with PPAR-γ H were significantly lower than those with PP...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C37-C38
Hauptverfasser: Xu, Chengzhang, Wang, Jingfeng, Wang, Shaohua, Liu, Wenhao, Lin, Yongqing, Zhang, Haifeng, Chen, Yangxin
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Connexin 43
Correlation
Heart
Peroxisome proliferator-activated receptors
Rodents
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Zusammenfassung:Methods Relative young (3 weeks) transgenetic cardiac-specific PPAR-γ(MHC-PPAR-γ) overexpression mice with low (PPAR-γ L) and high (PPAR-γ H) levels, and control mice were used. Results Cx43 contents, both in mRNA and protein levels, in heart with PPAR-γ H were significantly lower than those with PPAR-γ L and control heart. [...]Cx43 mRNA levels tended to be negatively correlated to MHC-PPAR-γ (r = -0.38; P
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.129