GW28-e0155 Decrease Lean Mass and Increase Fat Mass of SGA Adult Rats Associated with Down-Regulation of the mTOR/S6K Pathway in Skeletal Muscle

GW28-e0155 Decrease Lean Mass and Increase Fat Mass of SGA Adult Rats Associated with Down-Regulation of the mTOR/S6K Pathway in Skeletal Muscle

Results Compared to AGA adult rats, SGA adult rats showed increased FM % [(18.80±2.01) % vs (14.48±1.67) %, P < 0.01] and adipocyte area of visceral fat mass [(6834.34±665.39) μm2 vs (5763.71±468.59) μm2, P < 0.01] and decreased LM% [(78.72±1.84) % vs (83.44±1.61) %, P < 0.01] and cross sec...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C184-C184
Hauptverfasser: Yu, Muxue, Guo, Chuyi, Deng, Linxia, Shen, Zhenyu, Qiu, Xiaoshan
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Body composition
Body fat
Cardiology
Kinases
Musculoskeletal system
Protein synthesis
Proteins
Rats
Rodents
Skeletal muscle
TOR protein
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Zusammenfassung:Results Compared to AGA adult rats, SGA adult rats showed increased FM % [(18.80±2.01) % vs (14.48±1.67) %, P < 0.01] and adipocyte area of visceral fat mass [(6834.34±665.39) μm2 vs (5763.71±468.59) μm2, P < 0.01] and decreased LM% [(78.72±1.84) % vs (83.44±1.61) %, P < 0.01] and cross sectional area of skeletal muscle fibers [(2658.17±247.85) μm2 vs (3385.11±273.39) μm2, P < 0.01]. Conclusions Decrease lean mass and increase fat mass of SGA adult rats associated with down-regulation of the mTOR/S6K pathway in skeletal muscle.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.679