GW28-e1202 Advanced glycation end-products induced electrical remodeling in atrial myocytes in the type 2 diabetic mellitus

GW28-e1202 Advanced glycation end-products induced electrical remodeling in atrial myocytes in the type 2 diabetic mellitus

Methods The cardiac function of Zucker Diabetic Fatty (ZDF) rats, a model of type 2 diabetes, was detected with echocardiography. Conclusions AGEs could affect the expression and function of ion channels in atrial myocytes, which suggested that AGEs may be related to the atrial electrical remodeling...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C46-C46
Hauptverfasser: Hui, Yang, Su-juan, Kuang, Fang, Rao, Xiao-ying, Liu, Zhixin, Shan, Qiuxiong, Lin, Xiaohong, Li, Jiening, Zhu, Shulin, Wu, Chunyu, Deng
Format: Artikel
Sprache:eng
Schlagworte:
Advanced glycosylation end products
Cardiac arrhythmia
Cardiology
Diabetes
Diabetes mellitus
Glycosylation
Myocytes
Rodents
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Zusammenfassung:Methods The cardiac function of Zucker Diabetic Fatty (ZDF) rats, a model of type 2 diabetes, was detected with echocardiography. Conclusions AGEs could affect the expression and function of ion channels in atrial myocytes, which suggested that AGEs may be related to the atrial electrical remodeling and contribute to the atrial fibrillation in diabetes.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.159