GW28-e1078 Study of CYP2C9 and VKORC1 gene polymorphism on warfarin steady-state therapeutic dose and individual anticoagulation effect

Objectives The aims of the study were to explore the genotype and allele frequency of CYP2C9 and VKORC1 in Shaanxi Han nationality, to observe the effect of gene polymorphism and clinical features on warfarin steady-state therapeutic dose and the relationship between individualized recommended treatment dose and steady-state therapeutic dose of warfarin. Conclusions CYP2C9 and VKORC1 gene polymorphism can accurately predict the warfarin steady-state treatment dose, which could reduce the occurrence of drug-related adverse events and optimize the therapeutic strategies of oral anticoagulant therapy.