GW28-e0612 Liver X receptor agonist T0901317 ameliorates sepsis-induced myocardial injury and dysfunction: the role of SIRT1 signaling

Methods Male cardiac-specific SIRT1 knockout mice (SIRT1-/- ) mice and their wild-type littermates were subjected to sepsis by cecal ligation and puncture (CLP). SIRT1 signal and its substrates were also detected by Western Blot Results Our data showed that LXR agonist protected against CLP-induced myocardial injury and dysfunction, as evidenced by improved myocardial morphological changes, improved hypotension, reduced serum concentration of biochemical indices of heart injury(AST, LDH, CK and CK-MB), and elevation of cardiac functional parameters(LVEF 55.6±2.2% vs. 64.1±3.4%, respectively, N=11-14, p=0.0005).