GW28-e0192 Preliminary study on the role of AKAP1 in the development of diabetes mellitus

Results Here, we showed that AKAP1-/- knockout mice constructed by CRISPR/Cas9 technology are prone to obesity, hepatic steatosis, and whole-body insulin resistance in diabetes induced by high-fat diet. [...]we demonstrated that the up-regulation of AKAP1 can improve the cardiac ejection function, reduce the collagen content of myocardial tissue, alleviate myocardial hypertrophy, and ameliorate myocardial ischemia injury in db/db mice. [...]our results indicated that AKAP1 deficiency increased the mitochondrial morphological abnormalities in the major tissues of diabetic mice, and up-regulation of AKAP1 expression could significantly improve the mitochondrial morphology of db/db mice.