GW28-e0894 Impaired autophagosome clearance triggers myocardial necroptosis in ischemia/reperfusion injury

GW28-e0894 Impaired autophagosome clearance triggers myocardial necroptosis in ischemia/reperfusion injury

In young hearts, the autophagy substrate Sequestosome1 (p62/SQSTMl) was increased in ischemia and was degraded in reperfusion, while aged hearts exhibited increased p62 at basal and further accumulation during MI/R because of disabled degradation. Aged mice subjected to MI/R endured greater myocardi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C33-C33
Hauptverfasser: Li, Chen, Xue, Han, Yang, Zheng, Shi, Zhaoling, Zhang, Bo, Yu, Lu, Ma, Heng
Format: Artikel
Sprache:eng
Schlagworte:
Autophagy
Cardiology
Ischemia
Necroptosis
Reperfusion
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In young hearts, the autophagy substrate Sequestosome1 (p62/SQSTMl) was increased in ischemia and was degraded in reperfusion, while aged hearts exhibited increased p62 at basal and further accumulation during MI/R because of disabled degradation. Aged mice subjected to MI/R endured greater myocardial necroptosis, as evidenced by reductions in lactate dehydrogenase (LDH) release and Evans blue dye (EBD) penetration.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.114