GW28-e0736 Digoxin-induced Anemia among Patients with Atrial Fibrillation and Heart Failure: Clinical Data Analysis and Drug-gene Interaction Network

GW28-e0736 Digoxin-induced Anemia among Patients with Atrial Fibrillation and Heart Failure: Clinical Data Analysis and Drug-gene Interaction Network

Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Func...

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Veröffentlicht in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C26-C27
Hauptverfasser: Lin, Yubi, Xue, Yumei, He, Siqi, Feng, Ruiling, Xu, Zhe, Chen, Wanqun, Huang, Zifeng, Liu, Yang, Zhang, Qianhuan, Zhang, Bin, Wang, Kejian, Wu, Shulin
Format: Artikel
Sprache:eng
Schlagworte:
Anemia
Beta blockers
Cardiac arrhythmia
Cardiology
Data analysis
Data processing
Digoxin
Fibrillation
Heart
Heart diseases
Heart failure
Iron deficiency
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Zusammenfassung:Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14-1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33-1.59-, P =4.27x10-5). Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.091