Arylative Cyclization of Indole‐1‐carboxamides with 1,6‐Enynes for the Synthesis of Polycyclic Indole Scaffolds

A new alkyne annulation strategy has been developed for the synthesis of polycyclic indole derivatives through a cascade of C–H annulation and Michael addition reactions. This is the first report on sequential alkyne annulation and aza‐Michael addition reactions of indole‐1‐carboxamides with alkyne tethered substrates. A facile synthesis of polycyclic indole derivatives is reported through a sequential C–C and C–N bond formation using transition metal catalysis.