Co-infection with human immunodeficiency virus and tuberculosis

In an HIV-negative population, only up to 10% of people infected with M. tuberculosis develops TB; approximately 5% will develop primary infection in the first two years of exposure and 5% will develop disease due to reactivation of the latent infection at some time during their life. Diagnosis Microscopy and culture The diagnosis of tuberculosis ultimately rests on the detection of M. tuberculosis , either by microscopy or culture of the appropriate body fluid or tissue.