Isoflavin‐β modifies muscle oxidative stress and prevents a thyrotoxicosis‐induced loss of muscle mass in rats

ABSTRACT Introduction We sought to verify whether isoflavin‐beta (Iso‐β), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis‐induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention. Methods Two experimental perio...

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Veröffentlicht in:Muscle & nerve 2017-11, Vol.56 (5), p.975-981
Hauptverfasser: Marinello, Poliana C., Bernardes, Sara S., Guarnier, Flávia A., Silva, Thamara N.X., Borges, Fernando H., Lopes, Natália M.D., Simão, Andréa N.C., Armani, André, Cecchini, Rubens, Cecchini, Alessandra L.
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Sprache:eng
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Zusammenfassung:ABSTRACT Introduction We sought to verify whether isoflavin‐beta (Iso‐β), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis‐induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention. Methods Two experimental periods of thyrotoxicosis induction were used in Wistar rats: 3 and 5 days to assess Iso‐β effects before and after thyrotoxicosis‐induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed. Results Iso‐β prevented the loss of gastrocnemius mass in thyrotoxic rats through the prevention of muscle OS generation during thyrotoxicosis, increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome c oxidase activity, lipid peroxidation, and protein carbonyl content. Conclusion Iso‐β decreased oxidative modification of proteins, which is known to exert a major role during proteolysis induction and is present in thyrotoxic myopathy, highlighting the potential action of Iso‐β in this complication of the disease. Muscle Nerve 56: 975–981, 2017
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25546