Rapid Detection of Sildenafil Drugs in Liquid Nutraceuticals Based on Surface‐Enhanced Raman Spectroscopy Technology

In this study, surface‐enhanced Raman spectroscopy (SERS) technology was used to rapidly detect illegally added sildenafil drugs. A detailed attribution analysis by density functional theory (DFT) was used to guide specific experiments. The Raman signals were obtained from a silver colloid (Ag col)...

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Veröffentlicht in:Chinese journal of chemistry 2017-10, Vol.35 (10), p.1522-1528
Hauptverfasser: Zhao, Hang, Hasi, Wuliji, Bao, Lin, Han, Siqingaowa, Sha, Xuanyu, Sun, Jia, Lou, Xiutao, Lin, Dianyang, Lv, Zhiwei
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Sprache:eng
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Zusammenfassung:In this study, surface‐enhanced Raman spectroscopy (SERS) technology was used to rapidly detect illegally added sildenafil drugs. A detailed attribution analysis by density functional theory (DFT) was used to guide specific experiments. The Raman signals were obtained from a silver colloid (Ag col) substrate, and they increased in the presence of the mineral salt, potassium iodide (KI). These methods detected sildenafil in aqueous solutions as low as 1 µg/mL with high signal uniformity (RSD=3.77%). Prior to this study, traditional Raman techniques detected substances in solid samples only. Here, Raman technology detected low contents of sildenaful drugs in liquid nutraceuticals. Therefore, SERS technology has great potential for on‐site and real‐time detection of illegal drugs in water and in liquid nutraceuticals. A detailed attribution analysis by density functional theory (DFT) was used to guide the surface‐enhanced Raman spectroscopy experiments. The SERS signals were obtained from a silver colloid (Ag col) substrate and mineral salts. Here, Raman technology detected low contents of sildenaful drugs in liquid nutraceuticals. Therefore, SERS technology has great potential for on‐site and real‐time detection of illegal drugs in water and in liquid nutraceuticals.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201700168