Microwave-assisted synthesis of bis(N-substituted thiazol-2-amine) derivatives and their biological activities

Microwave-assisted synthesis of bis(N-substituted thiazol-2-amine) derivatives and their biological activities

New 4,4′-(4,6-dimethoxy-1,3-phenylene)-bis( -substituted thiazol-2-amine) derivatives were synthesized from 1,1′-(4,6-dimethoxy-1,3-phenylene)-bis(2-bromoethanone) and substituted thioureas under conventional and microwave irradiation conditions. All products were subjected to antibacterial and anti...

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Veröffentlicht in:Heterocyclic communications 2017-10, Vol.23 (5), p.405-409
Hauptverfasser: Baba, N.H. Kumar, Ashok, D., Rao, Boddu Ananda, Sarasija, Madderla, Murthy, N.Y.S., Srinivasarao, Vankadari, Parthasarathy, Tigulla
Format: Artikel
Sprache:eng
Schlagworte:
anti-TB
antibacterial
Derivatives
E coli
microwave irradiation
thiazole
Thioureas
Tuberculosis
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Zusammenfassung:New 4,4′-(4,6-dimethoxy-1,3-phenylene)-bis( -substituted thiazol-2-amine) derivatives were synthesized from 1,1′-(4,6-dimethoxy-1,3-phenylene)-bis(2-bromoethanone) and substituted thioureas under conventional and microwave irradiation conditions. All products were subjected to antibacterial and anti-TB evaluation. Some of the compounds exhibit good activities against (+ve), (−ve) strains and H37Rv.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2017-0129