Design, Development and Evaluation of Buccal Tablets of Pregabalin

[...]buccal drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. Methods Drug- Excipient Compatibility study using FTIR Drug and excipients interaction was checked by comparing the FT-IR spectra of pure drug Pregabalin and FT-IR spectra of the physical mixture of drug and excipients. According to Noorana tehseen et al, F2,F5, F8, F11, F14, F17 formulations are prepared by using HPMCK4M 1.25, 3.75, 7.5, 11.25, 15 and18.75. the thickness of these formulations shows 2.51, 2.62, 2.46, 2.37, 2.42, 2.55 and the hardness is 3.6, 3.7, 3.5, 3.6, 3.7, 3.8. [...]Accelerated stability studies were carried out for 3 months, no significant change in the physical properties, drug content, and dissolution rate of formulation F6 was observed .As such formulation F6 developed is considered as an best formulations of Pregabalin. [...]the study fulfilled the objective of developing efficient buccal tablets of Pregabalin.