Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study

The timely assessment of these symptoms during perimenopausal period can decrease the psychological burden that women encounter during this transition period. [...]most of the studies' focus on study of these symptoms following menopause, very few studies have given importance to PM transition symptoms among middle-aged women. A cross-sectional study that focused on the relative influence of menopausal status on blood pressure levels of healthy women aged 35-60 years showed that both SBP and diastolic blood pressure (DBP) changed with menopausal status. [...]the anovulatory cycles may be often associated with elevated levels of estradiol. [...]the main cause for PM fluctuations in estradiol is a reduced follicle pool as well as reduced responsiveness of aging ovary to follicle stimulating hormone (FSH). [...]greater circulating amounts of FSH are needed to initiate folliculogenesis which leads to overstimulation of the ovary causing, relative hyperestrogenemia during this transition period.