A Multifunctional Mineral Excipient

[...]the dissolution rate of FCC loaded with NP and MBZ was found to be faster than that of the FCC-API mixtures. Because only low percentages of amorphous NP (8.9%) and MB (12.5%) were detected, the authors concluded that the faster dissolution was related to the locally increased solubility caused by the larger surface area and not due to the presence of an amorphous API. [...]the FCC tablets' combination of high tensile strength and high porosity indicated that FCC is suitable for use in ODTs as a pharmaceutical excipient. [...]from a regulatory point of view, FCC has the advantage of being a co-processed excipient composed of only two monographed minerals. [...]it offers the possibility of multiple functionalities with simple chemistry and a straightforward granule and tablet manufacturing process.