Synthesis of β-cycloalkylglycosides of Muramyl Dipeptide

Synthesis of β-cycloalkylglycosides of Muramyl Dipeptide

β-Cyclooctyl-, β-cyclodecyl-, and β-cyclopentadecylglycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine were prepared in yields of 39, 18, and 25%, respectively, (calculated for muramic acid) via the reaction of β-cycloalkyl-4,6-O-isopropylidene-N-acetyl-D-muramic acids with the benzyl ester of L-A...

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Veröffentlicht in:Chemistry of natural compounds 2017-09, Vol.53 (5), p.929-932
Hauptverfasser: Zemlyakov, A. E., Tsikalova, V. N., Tsikalov, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
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Zusammenfassung:β-Cyclooctyl-, β-cyclodecyl-, and β-cyclopentadecylglycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine were prepared in yields of 39, 18, and 25%, respectively, (calculated for muramic acid) via the reaction of β-cycloalkyl-4,6-O-isopropylidene-N-acetyl-D-muramic acids with the benzyl ester of L-Ala-D-iGln using the HOSu/DCC method followed by deprotection.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-017-2157-2