Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides
A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide ( 8e ) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazol...
Gespeichert in:
| Veröffentlicht in: | Medicinal chemistry research 2017-10, Vol.26 (10), p.2568-2582 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2582 |
|---|---|
| container_issue | 10 |
| container_start_page | 2568 |
| container_title | Medicinal chemistry research |
| container_volume | 26 |
| creator | Divya, Kuppi Reddy Gari Sowmya, Donthamsetty V. Durgamma, Suram Tharanath, Vadlamudi Gopal, Divi Venkataramana Sai Kumar, Malaka Venkateshwarulu Jyothi Appa Rao, Chippada Padmaja, Adivireddy Padmavathi, Venkatapuram |
| description | A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide (
8e
) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides (
8b
,
8e
) exhibited antiviral activity on BHK 21 cell lines with IC
50
63.5, 44.5 µg/mL, respectively. The compound
8e
inhibited cytopathic changes induced by Blue Tongue Virus in cell lines. |
| doi_str_mv | 10.1007/s00044-017-1956-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1947101729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1947101729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-f54b65c4b4fc8dbf15ed4c159c8b62f9e83077be0a83ae34ebcaefb6997322513</originalsourceid><addsrcrecordid>eNp1ULlOxDAUtBBILAsfQBeJlsDzlaNEKy5pJQqgobEc5xm8yibBziLC1-MQChqqecfMO4aQUwoXFCC_DAAgRAo0T2kpsxT2yIJKKdKCMtiPMcSYScYPyVEIGwCeg5AL8vI4tsMbBhfOE90Orvt0dcQpqX8KH87rJul916MfHIaks0k_erd1tWvHJuwaq7fd2CT6q2smMDjo2MRwTA6sbgKe_OKSPN9cP63u0vXD7f3qap0aTrMhtVJUmTSiEtYUdWWpxFoYKktTVBmzJRYc8rxC0AXXyAVWRqOtsrLMOWOS8iU5m-fGI993GAa16Xa-jSsVLUVOoyesjCw6s4zvQvBoVR-f0H5UFNRkoZotVJGuJgsVRA2bNSFy21f0fyb_K_oGSyl2LA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1947101729</pqid></control><display><type>article</type><title>Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides</title><source>SpringerNature Journals</source><creator>Divya, Kuppi Reddy Gari ; Sowmya, Donthamsetty V. ; Durgamma, Suram ; Tharanath, Vadlamudi ; Gopal, Divi Venkataramana Sai ; Kumar, Malaka Venkateshwarulu Jyothi ; Appa Rao, Chippada ; Padmaja, Adivireddy ; Padmavathi, Venkatapuram</creator><creatorcontrib>Divya, Kuppi Reddy Gari ; Sowmya, Donthamsetty V. ; Durgamma, Suram ; Tharanath, Vadlamudi ; Gopal, Divi Venkataramana Sai ; Kumar, Malaka Venkateshwarulu Jyothi ; Appa Rao, Chippada ; Padmaja, Adivireddy ; Padmavathi, Venkatapuram</creatorcontrib><description>A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide (
8e
) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides (
8b
,
8e
) exhibited antiviral activity on BHK 21 cell lines with IC
50
63.5, 44.5 µg/mL, respectively. The compound
8e
inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-017-1956-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetic acid ; Antioxidants ; Antiviral activity ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Cell Biology ; Cell lines ; Original Research ; Pharmacology/Toxicology ; Tongue ; Viruses</subject><ispartof>Medicinal chemistry research, 2017-10, Vol.26 (10), p.2568-2582</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-f54b65c4b4fc8dbf15ed4c159c8b62f9e83077be0a83ae34ebcaefb6997322513</citedby><cites>FETCH-LOGICAL-c316t-f54b65c4b4fc8dbf15ed4c159c8b62f9e83077be0a83ae34ebcaefb6997322513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-017-1956-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-017-1956-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Divya, Kuppi Reddy Gari</creatorcontrib><creatorcontrib>Sowmya, Donthamsetty V.</creatorcontrib><creatorcontrib>Durgamma, Suram</creatorcontrib><creatorcontrib>Tharanath, Vadlamudi</creatorcontrib><creatorcontrib>Gopal, Divi Venkataramana Sai</creatorcontrib><creatorcontrib>Kumar, Malaka Venkateshwarulu Jyothi</creatorcontrib><creatorcontrib>Appa Rao, Chippada</creatorcontrib><creatorcontrib>Padmaja, Adivireddy</creatorcontrib><creatorcontrib>Padmavathi, Venkatapuram</creatorcontrib><title>Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide (
8e
) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides (
8b
,
8e
) exhibited antiviral activity on BHK 21 cell lines with IC
50
63.5, 44.5 µg/mL, respectively. The compound
8e
inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.</description><subject>Acetic acid</subject><subject>Antioxidants</subject><subject>Antiviral activity</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Cell lines</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Tongue</subject><subject>Viruses</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1ULlOxDAUtBBILAsfQBeJlsDzlaNEKy5pJQqgobEc5xm8yibBziLC1-MQChqqecfMO4aQUwoXFCC_DAAgRAo0T2kpsxT2yIJKKdKCMtiPMcSYScYPyVEIGwCeg5AL8vI4tsMbBhfOE90Orvt0dcQpqX8KH87rJul916MfHIaks0k_erd1tWvHJuwaq7fd2CT6q2smMDjo2MRwTA6sbgKe_OKSPN9cP63u0vXD7f3qap0aTrMhtVJUmTSiEtYUdWWpxFoYKktTVBmzJRYc8rxC0AXXyAVWRqOtsrLMOWOS8iU5m-fGI993GAa16Xa-jSsVLUVOoyesjCw6s4zvQvBoVR-f0H5UFNRkoZotVJGuJgsVRA2bNSFy21f0fyb_K_oGSyl2LA</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Divya, Kuppi Reddy Gari</creator><creator>Sowmya, Donthamsetty V.</creator><creator>Durgamma, Suram</creator><creator>Tharanath, Vadlamudi</creator><creator>Gopal, Divi Venkataramana Sai</creator><creator>Kumar, Malaka Venkateshwarulu Jyothi</creator><creator>Appa Rao, Chippada</creator><creator>Padmaja, Adivireddy</creator><creator>Padmavathi, Venkatapuram</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20171001</creationdate><title>Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides</title><author>Divya, Kuppi Reddy Gari ; Sowmya, Donthamsetty V. ; Durgamma, Suram ; Tharanath, Vadlamudi ; Gopal, Divi Venkataramana Sai ; Kumar, Malaka Venkateshwarulu Jyothi ; Appa Rao, Chippada ; Padmaja, Adivireddy ; Padmavathi, Venkatapuram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-f54b65c4b4fc8dbf15ed4c159c8b62f9e83077be0a83ae34ebcaefb6997322513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetic acid</topic><topic>Antioxidants</topic><topic>Antiviral activity</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Cell Biology</topic><topic>Cell lines</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Tongue</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Divya, Kuppi Reddy Gari</creatorcontrib><creatorcontrib>Sowmya, Donthamsetty V.</creatorcontrib><creatorcontrib>Durgamma, Suram</creatorcontrib><creatorcontrib>Tharanath, Vadlamudi</creatorcontrib><creatorcontrib>Gopal, Divi Venkataramana Sai</creatorcontrib><creatorcontrib>Kumar, Malaka Venkateshwarulu Jyothi</creatorcontrib><creatorcontrib>Appa Rao, Chippada</creatorcontrib><creatorcontrib>Padmaja, Adivireddy</creatorcontrib><creatorcontrib>Padmavathi, Venkatapuram</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Divya, Kuppi Reddy Gari</au><au>Sowmya, Donthamsetty V.</au><au>Durgamma, Suram</au><au>Tharanath, Vadlamudi</au><au>Gopal, Divi Venkataramana Sai</au><au>Kumar, Malaka Venkateshwarulu Jyothi</au><au>Appa Rao, Chippada</au><au>Padmaja, Adivireddy</au><au>Padmavathi, Venkatapuram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2017-10-01</date><risdate>2017</risdate><volume>26</volume><issue>10</issue><spage>2568</spage><epage>2582</epage><pages>2568-2582</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide (
8e
) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides (
8b
,
8e
) exhibited antiviral activity on BHK 21 cell lines with IC
50
63.5, 44.5 µg/mL, respectively. The compound
8e
inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-017-1956-0</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1054-2523 |
| ispartof | Medicinal chemistry research, 2017-10, Vol.26 (10), p.2568-2582 |
| issn | 1054-2523 1554-8120 |
| language | eng |
| recordid | cdi_proquest_journals_1947101729 |
| source | SpringerNature Journals |
| subjects | Acetic acid Antioxidants Antiviral activity Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Cell Biology Cell lines Original Research Pharmacology/Toxicology Tongue Viruses |
| title | Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A06%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20antioxidant,%20and%20antiviral%20properties%20of%20pyrimidinylsulfamoyl%20azolyl%20acetamides&rft.jtitle=Medicinal%20chemistry%20research&rft.au=Divya,%20Kuppi%20Reddy%20Gari&rft.date=2017-10-01&rft.volume=26&rft.issue=10&rft.spage=2568&rft.epage=2582&rft.pages=2568-2582&rft.issn=1054-2523&rft.eissn=1554-8120&rft_id=info:doi/10.1007/s00044-017-1956-0&rft_dat=%3Cproquest_cross%3E1947101729%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1947101729&rft_id=info:pmid/&rfr_iscdi=true |