Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides

Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides

A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide ( 8e ) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazol...

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Veröffentlicht in:Medicinal chemistry research 2017-10, Vol.26 (10), p.2568-2582
Hauptverfasser: Divya, Kuppi Reddy Gari, Sowmya, Donthamsetty V., Durgamma, Suram, Tharanath, Vadlamudi, Gopal, Divi Venkataramana Sai, Kumar, Malaka Venkateshwarulu Jyothi, Appa Rao, Chippada, Padmaja, Adivireddy, Padmavathi, Venkatapuram
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Antioxidants
Antiviral activity
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell lines
Original Research
Pharmacology/Toxicology
Tongue
Viruses
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Zusammenfassung:A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide ( 8e ) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides ( 8b , 8e ) exhibited antiviral activity on BHK 21 cell lines with IC 50 63.5, 44.5 µg/mL, respectively. The compound 8e inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-1956-0