The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+-A[beta] Complex

The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+-A[beta] Complex

A prominent current hypothesis is that impaired metal ion homeostasis may contribute to Alzheimer's disease (AD). We elucidate the interaction of Cu2+ with wild-type (WT) A[beta]1-40 and the genetic variants A2T and A2V which display increasing pathogenicity as A2T

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Veröffentlicht in:Chemistry : a European journal 2017-10, Vol.23 (55), p.13591
Hauptverfasser: Somavarapu, Arun K, Shen, Fei, Teilum, Kaare, Zhang, Jingdong, Mossin, Susanne, Thulstrup, Peter W, Bjerrum, Morten J, Tiwari, Manish K, Szunyogh, Daniel, Sotofte, Peter M, Kepp, Kasper P, Hemmingsen, Lars
Format: Artikel
Sprache:eng
Schlagworte:
Agglomeration
Alzheimer's disease
Atomic force microscopy
Atomic structure
Cadmium
Chemistry
Circular dichroism
Copper
Dichroism
Electron paramagnetic resonance
Homeostasis
Kinetics
Lag phase
Metals
Microscopy
Neurodegenerative diseases
Pathogenicity
Pathogens
pH effects
Spectroscopy
Spectrum analysis
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Zusammenfassung:A prominent current hypothesis is that impaired metal ion homeostasis may contribute to Alzheimer's disease (AD). We elucidate the interaction of Cu2+ with wild-type (WT) A[beta]1-40 and the genetic variants A2T and A2V which display increasing pathogenicity as A2T
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201703440