Therapeutic efficacy of Morus alba L. against N-nitrosodiethylamine induced subchronic hepatic ailment in rats

The current study was carried out with a focus on the therapeutic potential of a polyphenolic extract of mulberry ( Morus alba L.) leaves on hepatic ailments induced due to N-nitrosodiethylamine (NDEA) a compound present in most of our daily foods. Hepatic injury was induced by administration of NDEA intraperitoneally at a dose of 70 mg/kg once in a week for three weeks. Mulberry leaf extract at the doses of 200, 400, and 800 mg/kg, p.o. was co-administered as a preventive drug to NDEA intoxicated rats for 21 days. After the experimental period serum and liver tissue samples were collected for biochemical investigations from sacrificed animals. NDEA administrated rats showed elevated levels of SGOT, SGPT and SALP which were shifted towards normal after cotreatment with leaf extract in a dose dependent manner. Mulberry leaf extracts significantly ( P