Evaluation of mesoporous imprinted silicas as MSPD selective sorbents of ketoprofen in powder milk

•New mesoporous imprinted silicas were prepared using ketoprofen as template.•Materials were evaluated as sorbent in matrix solid phase dispersion for extraction of NSAIDs.•Results show that SBA-15-MIS-2 is appropriate to selective extraction of ketoprofen in powder milk. Two molecularly imprinted mesoporous silicas were synthesized using different ratios of ketoprofen as template molecule and amino-functionalized SBA-15 as support. The materials synthesized were characterized and evaluated as selective sorbents for matrix solid phase dispersion (MSPD) of ketoprofen in the presence of other nonsteroidal anti-inflammatory drugs (NSAIDs) in powder milk samples.