Review on in-situ nasal gel drug delivery system

[...]are the nasal vasculature shows cyclical changes of congestion giving rise to the nasal cycle. [...]broad ranges of metabolic enzymes are present in the nasal mucosa. [...]pathological conditions like rhinitis, common cold can also affect absorption of drugs from nasal cavity and pH of nasal cavity also affects permeation of drug. [...]an adequate formulation buffer capacity may be required to maintain the pH. У Osmolarity: Drug absorption can be affected by tonicity of the formulation.