Nephroprotective effect of ethanol extract of Biophytum sensitivum (Linn.) DC in cisplatin-induced experimental renal damage in rats

[...]this study substantiated and confirmed the ethno-medical usefulness of B. sensitivum as nephroprotective and antioxidant agent. Grounded leaves are indicated for diuretic activity and powdered form for urolithiasis18.Recently antioxidant19, antibacterial20, antidiabetic21, antitumour22, antiinflammatory23and cardio-protective activities24were reported. [...]as the search for nephroprotective drug possessing significant antioxidant activities from natural sources has gained immense potential, this study was aimed to investigate the in vivo nephroprotective and antioxidant activity of ethanol extract of B. sensitivum (EEBS) in CDDP-induced nephrotoxicity in Wistar albino rats. [...]the therapeutic dose was taken as 250 mg/kg and 500 mg/kg body weight for nephroprotective and antioxidant studies. Concurrent administration of EEBS with CDDP showed a significant reduction in calcium excretion, but there was no significant difference in urinary level of potassium or magnesium excretion compared to CDDP- treated group. [...]prevention of hypercalciuric effect may probably be attributed to the protective effect of EEBS in CDDP- induced nephrotoxicity.