Underlining the pharmaceutical aspects associated with the development of pH responsive hydrogel

Hydrogel are one of the upcoming classes of polymer-based controlled release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogel also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. [1] Hydrogel are polymer-based controlled release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogel also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. Hydrogel have been widely used for drug delivery systems since they allow molecules of different sizes to diffuse into or out of the network for drug loading and release, respectively. Since the polymer chains of different hydrogel contain specific functional groups, hydrogel can be sensitive to changes in the surrounding environment, such as the changes in pH, temperature, and pressures. [...]when an optimized concentration of cross linkers like N, N' - methylene bisacrylamide are used then maximum entrapment efficiency is observed. [...]the release and unwanted degradation of drugs like insulin can be prevented by hydrogel based drug delivery devices.