Synthesis of O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) via Ni(II) complex of (S) tyrosine schiff’s base precursor

O-(1′-[ 18 F]fluoropropan-2′-yl)- l -tyrosine (1-[ 18 F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step process starting from RS-tyrosine, (S)BPB and Ni(II) chloride hexahydrate. The precursor was [ 18 F]radiofluorinated, followed by hydrolysis with 2 M HCl to obtain 1-[ 18 F]FPT. The reaction mixture was purified using neutral alumina column. Radiolabeling efficiency and radiochemical yield (after purification and decay uncorrected) was 60 and 5% respectively. Total time for synthesis was 70 min. This synthesis procedure for (1-[ 18 F]FPT) gave a radiochemical purity of 98% with enantiomeric purity of 93%, and can easily be adapted in any standard 2-[ 18 F]FDG synthesis module.