Nanobiomedicine: Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility (Adv. Healthcare Mater. 18/2017)

Nanobiomedicine: Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility (Adv. Healthcare Mater. 18/2017)

DNA origami nanostructures (purple double helix) can be coated with serum albumin proteins (green) to improve origami stability against DNA digesting enzymes, enhance delivery rates and, importantly, suppress the immune response. In article number 1700692, Henni Auvinen, Veikko Linko, Mauri Kostiain...

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Veröffentlicht in:Advanced healthcare materials 2017-09, Vol.6 (18), p.n/a
Hauptverfasser: Auvinen, Henni, Zhang, Hongbo, Nonappa, Kopilow, Alisa, Niemelä, Elina H., Nummelin, Sami, Correia, Alexandra, Santos, Hélder A., Linko, Veikko, Kostiainen, Mauri A.
Format: Artikel
Sprache:eng
Schlagworte:
Albumin
dendrons
Deoxyribonucleic acid
DNA
DNA binding
DNA origami
Drug delivery
Drug delivery systems
Enzymes
Immune response
Immune system
nanobiomedicine
Nanotechnology devices
Proteins
protein–polymer conjugates
Serum albumin
Stability
Therapeutic applications
Workers
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Zusammenfassung:DNA origami nanostructures (purple double helix) can be coated with serum albumin proteins (green) to improve origami stability against DNA digesting enzymes, enhance delivery rates and, importantly, suppress the immune response. In article number 1700692, Henni Auvinen, Veikko Linko, Mauri Kostiainen, and co‐workers present a straightforward and modular coating strategy that can bring DNA origami–based drug delivery vehicles and nanodevices closer to clinical applications.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201770093