Gross and Histopathological Study of Ziram Induced Subchronic Toxicity in Broiler Chickens

The present experimental work was conducted to elucidate the pathological changes in broiler chickens after ziram intoxication. For this study 120 apparently healthy broiler chicks were reared up to 2 weeks of age and allocated randomly to two groups, i.e. sub-chronic toxicity (N=90) and control group (N=30). Toxicity was induced in broiler chicks by giving 1 mg/kg body weight per day for the study period of 90 days in case of sub-chronic intoxication. At the end of the experimental period the investigations revealed depletion of lymphoid tissue from the lymphoid organs which were suggestive of immunosuppressive and immunomodulatory effects of ziram in chicken.