Protective role of prostaglandin E1 analog in indomethacin-induced deterioration in acute respiratory distress syndrome in rats

Acute Respiratory Distress Syndrome; Prostaglandins; Oleic Acid; Prostaglandin E1 Analog INTRODUCTION Acute respiratory distress syndrome (ARDS) is an inflammatory condition characterized by pulmonary edema, hypoxia, and massive influx of inflammatory cells as per the American Thoracic Society (ATS) guidelines. [9] The results of earlier study indicate the involvement of PGs in the pathophysiology of ARDS. [...]the present study was undertaken to identify the role of PGE1 analog in the indomethacininduced exacerbation in ARDS and to explore the possible mechanism. Protective role of prostaglandin E1 analog in indomethacininduced deterioration in acute respiratory distress syndrome in rats. Indomethacin exacerbates oleic acid induced acute respiratory distress syndrome in adult rats.